ROLE OF HNFA1 GENE VARIANTS IN PANCREATIC BETA CELLS FUNCTION AND GLYCAEMIC CONTROL IN YOUNG INDIVIDUALS WITH TYPE 1 DIABETES

Role of HNFA1 Gene Variants in Pancreatic Beta Cells Function and Glycaemic Control in Young Individuals with Type 1 Diabetes

The HNF1A transcription factor, implicated in the regulation of pancreatic beta cells, as well as in glucose and lipid metabolism, is responsible for type 3 maturity-onset diabetes of the young (MODY3).HNF1A is also involved in increased susceptibility to polygenic forms of diabetes, such as type 2 diabetes (T2D) Harnesses Pickup and gestational di

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THERAPY-RELATED MYELOID MALIGNANCIES IN MYELOMA

<p>Therapy related myeloid malignancies are an increasingly recognized treatment complication in patients undergoing therapy for multiple myeloma.The main predisposing factors are the alkylating agents, topoisomerase II inhibitors and radiotherapy, but recently questions have been raised regarding the immunomodulatory agent lenalidomide.Littl

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The risks of sleeping "too much". Survey of a National Representative Sample of 24671 adults (INPES health barometer).

BackgroundA significant U-shaped association between sleep duration and several morbidity (obesity, diabetes or cardiovascular disease) and mortality risks has been regularly reported.However, although the physiological pathways and risks associated with "too short sleep" (PurposeTo explore socio-demographic characteristics and comorbidities of "lo

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